diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index a8e4e17ac52e..3a9b3bc2c7ac 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -971,7 +971,8 @@ with pkgs;
   makeShellWrapper = makeSetupHook
     { deps = [ dieHook ];
       substitutions = {
-        shell = targetPackages.runtimeShell;
+        # targetPackages.runtimeShell only exists when pkgs == targetPackages (when targetPackages is not  __raw)
+        shell = if targetPackages ? runtimeShell then targetPackages.runtimeShell else throw "makeWrapper/makeShellWrapper must be in nativeBuildInputs";
       };
       passthru = {
         tests = tests.makeWrapper;