diff --git a/pkgs/tools/text/diffutils/default.nix b/pkgs/tools/text/diffutils/default.nix
index 040f363fa55d..8c4a160d4b1e 100644
--- a/pkgs/tools/text/diffutils/default.nix
+++ b/pkgs/tools/text/diffutils/default.nix
@@ -33,7 +33,8 @@ stdenv.mkDerivation rec {
     lib.optional (coreutils != null) "PR_PROGRAM=${coreutils}/bin/pr"
     ++ lib.optional (stdenv.buildPlatform != stdenv.hostPlatform) "gl_cv_func_getopt_gnu=yes";
 
-  doCheck = true;
+  # Test failure on QEMU only (#300550)
+  doCheck = !stdenv.buildPlatform.isRiscV64;
 
   meta = with lib; {
     homepage = "https://www.gnu.org/software/diffutils/diffutils.html";