diff --git a/pkgs/development/compilers/rust/rustc.nix b/pkgs/development/compilers/rust/rustc.nix
index 65d8920c4a4c..dc2e57d4284a 100644
--- a/pkgs/development/compilers/rust/rustc.nix
+++ b/pkgs/development/compilers/rust/rustc.nix
@@ -1,4 +1,5 @@
 { stdenv, removeReferencesTo, pkgsBuildBuild, pkgsBuildHost, pkgsBuildTarget
+, targetPackages
 , fetchurl, file, python3
 , llvm_10, darwin, cmake, rust, rustPlatform
 , pkgconfig, openssl
@@ -92,6 +93,8 @@ in stdenv.mkDerivation rec {
     "${setTarget}.llvm-config=${llvmSharedForTarget}/bin/llvm-config"
   ] ++ optionals (stdenv.isLinux && !stdenv.targetPlatform.isRedox) [
     "--enable-profiler" # build libprofiler_builtins
+  ] ++ optionals stdenv.targetPlatform.isMusl [
+    "${setTarget}.musl-root=${targetPackages.stdenv.cc.libc}"
   ];
 
   # The bootstrap.py will generated a Makefile that then executes the build.