diff --git a/pkgs/development/python-modules/pyqtwebengine/default.nix b/pkgs/development/python-modules/pyqtwebengine/default.nix
index c86fe165d4fc..c11dcad4d7d3 100644
--- a/pkgs/development/python-modules/pyqtwebengine/default.nix
+++ b/pkgs/development/python-modules/pyqtwebengine/default.nix
@@ -1,10 +1,12 @@
-{ lib, pythonPackages, pkg-config
+{ lib, stdenv, pythonPackages, pkg-config
 , qmake, qtbase, qtsvg, qtwebengine
 , wrapQtAppsHook
+, darwin
 }:
 
 let
   inherit (pythonPackages) buildPythonPackage python isPy27 pyqt5 enum34 sip pyqt-builder;
+  inherit (darwin) autoSignDarwinBinariesHook;
 in buildPythonPackage rec {
   pname = "PyQtWebEngine";
   version = "5.15.4";
@@ -33,6 +35,8 @@ in buildPythonPackage rec {
     qtwebengine
     pyqt-builder
     pythonPackages.setuptools
+  ] ++ lib.optionals (stdenv.isDarwin && stdenv.isAarch64) [
+    autoSignDarwinBinariesHook
   ];
 
   buildInputs = [