diff --git a/pkgs/development/python-modules/pyside2-tools/default.nix b/pkgs/development/python-modules/pyside2-tools/default.nix
index a96ea5d32ff8..9f1f94ffecbb 100644
--- a/pkgs/development/python-modules/pyside2-tools/default.nix
+++ b/pkgs/development/python-modules/pyside2-tools/default.nix
@@ -6,6 +6,13 @@ stdenv.mkDerivation {
 
   inherit (pyside2) version src;
 
+  patches = [
+    # Upstream has a crazy build system only geared towards producing binary
+    # wheels distributed via pypi.  For this, they copy the `uic` and `rcc`
+    # binaries to the wheel.
+    ./remove_hacky_binary_copying.patch
+  ];
+
   postPatch = ''
     cd sources/pyside2-tools
   '';
@@ -18,8 +25,16 @@ stdenv.mkDerivation {
     "-DBUILD_TESTS=OFF"
   ];
 
+  # The upstream build system consists of a `setup.py` whichs builds three
+  # different python libraries and calls cmake as a subprocess.  We call cmake
+  # directly because that's easier to get working.  However, the `setup.py`
+  # build also creates a few wrapper scripts, which we replicate here:
   postInstall = ''
     rm $out/bin/pyside_tool.py
+
+    for tool in uic rcc; do
+      makeWrapper "$(command -v $tool)" $out/bin/pyside2-$tool --add-flags "-g python"
+    done
   '';
 
   postFixup = ''
diff --git a/pkgs/development/python-modules/pyside2-tools/remove_hacky_binary_copying.patch b/pkgs/development/python-modules/pyside2-tools/remove_hacky_binary_copying.patch
new file mode 100644
index 000000000000..19dd8aaf101c
--- /dev/null
+++ b/pkgs/development/python-modules/pyside2-tools/remove_hacky_binary_copying.patch
@@ -0,0 +1,50 @@
+--- pyside-setup-opensource-src-5.14.2/sources/pyside2-tools/CMakeLists.txt~	2020-07-17 10:51:14.498291075 +0200
++++ pyside-setup-opensource-src-5.14.2/sources/pyside2-tools/CMakeLists.txt	2020-07-17 10:52:20.165336508 +0200
+@@ -46,47 +46,6 @@
+     set(EXE_EXT "")
+ endif()
+ 
+-set(TOOLS_PATH "${_qt5Core_install_prefix}/bin")
+-set(UIC_PATH "${TOOLS_PATH}/uic${EXE_EXT}")
+-set(RCC_PATH "${TOOLS_PATH}/rcc${EXE_EXT}")
+-if (APPLE)
+-    set(DESIGNER_PATH "${TOOLS_PATH}/Designer.app")
+-else()
+-    set(DESIGNER_PATH "${TOOLS_PATH}/designer${EXE_EXT}")
+-endif()
+-
+-install(FILES "${UIC_PATH}"
+-        DESTINATION bin
+-        PERMISSIONS
+-        OWNER_EXECUTE OWNER_WRITE OWNER_READ
+-        GROUP_EXECUTE GROUP_READ
+-        WORLD_EXECUTE WORLD_READ)
+-
+-install(FILES "${RCC_PATH}"
+-        DESTINATION bin
+-        PERMISSIONS
+-        OWNER_EXECUTE OWNER_WRITE OWNER_READ
+-        GROUP_EXECUTE GROUP_READ
+-        WORLD_EXECUTE WORLD_READ)
+-
+-if (EXISTS ${DESIGNER_PATH})
+-    if (APPLE)
+-        install(DIRECTORY "${DESIGNER_PATH}"
+-                DESTINATION bin
+-                FILE_PERMISSIONS
+-                OWNER_EXECUTE OWNER_WRITE OWNER_READ
+-                GROUP_EXECUTE GROUP_READ
+-                WORLD_EXECUTE WORLD_READ)
+-    else()
+-        install(FILES "${DESIGNER_PATH}"
+-                DESTINATION bin
+-                PERMISSIONS
+-                OWNER_EXECUTE OWNER_WRITE OWNER_READ
+-                GROUP_EXECUTE GROUP_READ
+-                WORLD_EXECUTE WORLD_READ)
+-    endif()
+-endif()
+-
+ configure_file("${CMAKE_CURRENT_SOURCE_DIR}/cmake_uninstall.cmake"
+                "${CMAKE_CURRENT_BINARY_DIR}/cmake_uninstall.cmake"
+                IMMEDIATE @ONLY)
diff --git a/pkgs/development/python-modules/pyside2/default.nix b/pkgs/development/python-modules/pyside2/default.nix
index e12db4d2e883..f9d07be5796b 100644
--- a/pkgs/development/python-modules/pyside2/default.nix
+++ b/pkgs/development/python-modules/pyside2/default.nix
@@ -3,11 +3,11 @@
 
 stdenv.mkDerivation rec {
   pname = "pyside2";
-  version = "5.12.6";
+  version = "5.14.2";
 
   src = fetchurl {
-    url = "https://download.qt.io/official_releases/QtForPython/pyside2/PySide2-${version}-src/pyside-setup-everywhere-src-${version}.tar.xz";
-    sha256 = "1n45l6xxyxs6cfp2l4rp8qs1c2fyfwyrdxa4qcpwfsqsi51rydsk";
+    url = "https://download.qt.io/official_releases/QtForPython/pyside2/PySide2-${version}-src/pyside-setup-opensource-src-${version}.tar.xz";
+    sha256 = "1cwjpv8qmjksi7cj4naw54h2afphw44chrf1pmfjamyyj8vz6ykw";
   };
 
   patches = [
diff --git a/pkgs/development/python-modules/pyside2/dont_ignore_optional_modules.patch b/pkgs/development/python-modules/pyside2/dont_ignore_optional_modules.patch
index 681e16a2bfd3..c9f17bea71b4 100644
--- a/pkgs/development/python-modules/pyside2/dont_ignore_optional_modules.patch
+++ b/pkgs/development/python-modules/pyside2/dont_ignore_optional_modules.patch
@@ -1,6 +1,6 @@
---- pyside-setup-everywhere-src-5.12.3/sources/pyside2/CMakeLists.txt~	2019-06-15 19:07:48.368704430 +0200
-+++ pyside-setup-everywhere-src-5.12.3/sources/pyside2/CMakeLists.txt	2019-06-15 19:08:04.429489908 +0200
-@@ -219,7 +219,7 @@
+--- pyside-setup-opensource-src-5.14.2/sources/cmake_helpers/helpers.cmake~	2020-07-17 10:29:30.555285529 +0200
++++ pyside-setup-opensource-src-5.14.2/sources/cmake_helpers/helpers.cmake	2020-07-17 10:29:49.817003683 +0200
+@@ -139,7 +139,7 @@
      # If the module was found, and also the module path is the same as the
      # Qt5Core base path, we will generate the list with the modules to be installed
      set(looked_in_message ". Looked in: ${${_name_dir}}")