diff --git a/pkgs/misc/dxvk/dxvk.nix b/pkgs/misc/dxvk/dxvk.nix
index e0a104ff354e..793264f9b30b 100644
--- a/pkgs/misc/dxvk/dxvk.nix
+++ b/pkgs/misc/dxvk/dxvk.nix
@@ -9,8 +9,15 @@
 , spirv-headers
 , vulkan-headers
 , SDL2
+, glfw
+, pkgsBuildHost
+, sdl2Support ? true
+, glfwSupport ? false
 }:
 
+# SDL2 and GLFW support are mutually exclusive.
+assert !sdl2Support || !glfwSupport;
+
 let
   # DXVK 2.0+ no longer vendors certain dependencies. This derivation also needs to build on Darwin,
   # which does not currently support DXVK 2.0, so adapt conditionally for this situation.
@@ -36,13 +43,13 @@ let
         ./darwin-thread-primitives.patch
       ];
     };
-    "2.0" = rec {
-      version = "2.0";
+    "2.1" = rec {
+      version = "2.1";
       src = fetchFromGitHub {
         owner = "doitsujin";
         repo = "dxvk";
         rev = "v${version}";
-        hash = "sha256-mSNFvoILsvm+CpWV7uRlb7DkjV7ctClSUdteNcF5EAY=";
+        hash = "sha256-A4KR11brfQbR56dGt371MRwMN/H6HFAU8TlFC97/bRs=";
         fetchSubmodules = true; # Needed for the DirectX headers and libdisplay-info
       };
       patches = [ ];
@@ -61,8 +68,14 @@ stdenv.mkDerivation {
     ++ lib.optionals isDxvk2 (
       [ spirv-headers vulkan-headers ]
       ++ lib.optional (!isWindows && sdl2Support) SDL2
+      ++ lib.optional (!isWindows && glfwSupport) glfw
     );
 
+  postPatch = lib.optionalString isDxvk2 ''
+    substituteInPlace "subprojects/libdisplay-info/tool/gen-search-table.py" \
+      --replace "/usr/bin/env python3" "${lib.getBin pkgsBuildHost.python3}/bin/python3"
+  '';
+
   # Build with the Vulkan SDK in nixpkgs.
   preConfigure = ''
     rm -rf include/spirv/include include/vulkan/include
@@ -77,7 +90,8 @@ stdenv.mkDerivation {
       "--buildtype" "release"
       "--prefix" "${placeholder "out"}"
     ]
-    ++ lib.optionals isCross [ "--cross-file" "build-win${arch}.txt" ];
+    ++ lib.optionals isCross [ "--cross-file" "build-win${arch}.txt" ]
+    ++ lib.optional glfwSupport "-Ddxvk_native_wsi=glfw";
 
   doCheck = isDxvk2 && !isCross;
 
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 0d09810ef2ff..cbc10e07eb80 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -37210,7 +37210,7 @@ with pkgs;
 
   dxvk = callPackage ../misc/dxvk { };
   dxvk_1 = callPackage ../misc/dxvk/dxvk.nix { dxvkVersion = "1.10"; };
-  dxvk_2 = callPackage ../misc/dxvk/dxvk.nix { dxvkVersion = "2.0"; };
+  dxvk_2 = callPackage ../misc/dxvk/dxvk.nix { dxvkVersion = "2.1"; };
 
   ecdsatool = callPackage ../tools/security/ecdsatool { };