diff --git a/pkgs/development/python-modules/python-rtmidi/default.nix b/pkgs/development/python-modules/python-rtmidi/default.nix
index 335a085277a0..58d6a1e72f55 100644
--- a/pkgs/development/python-modules/python-rtmidi/default.nix
+++ b/pkgs/development/python-modules/python-rtmidi/default.nix
@@ -1,5 +1,17 @@
-{ lib, buildPythonPackage, fetchPypi, isPy27
-, pkg-config, alsa-lib, libjack2, tox, flake8, alabaster
+{ lib
+, stdenv
+, buildPythonPackage
+, fetchPypi
+, isPy27
+, pkg-config
+, alsa-lib
+, libjack2
+, tox
+, flake8
+, alabaster
+, CoreAudio
+, CoreMIDI
+, CoreServices
 }:
 
 buildPythonPackage rec {
@@ -13,7 +25,15 @@ buildPythonPackage rec {
   };
 
   nativeBuildInputs = [ pkg-config ];
-  buildInputs = [ alsa-lib libjack2 ];
+  buildInputs = [
+    libjack2
+  ] ++ lib.optionals stdenv.isLinux [
+    alsa-lib
+  ] ++ lib.optionals stdenv.isDarwin [
+    CoreAudio
+    CoreMIDI
+    CoreServices
+  ];
   checkInputs = [
     tox
     flake8
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 894c218f94be..d64a8e40d718 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -8135,7 +8135,9 @@ in {
 
   python-registry = callPackage ../development/python-modules/python-registry { };
 
-  python-rtmidi = callPackage ../development/python-modules/python-rtmidi { };
+  python-rtmidi = callPackage ../development/python-modules/python-rtmidi {
+    inherit (pkgs.darwin.apple_sdk.frameworks) CoreAudio CoreMIDI CoreServices;
+  };
 
   python-sat = callPackage ../development/python-modules/python-sat { };