diff --git a/pkgs/development/python-modules/pandas/default.nix b/pkgs/development/python-modules/pandas/default.nix
index a2d16f603f5d..eddf3f74e0f3 100644
--- a/pkgs/development/python-modules/pandas/default.nix
+++ b/pkgs/development/python-modules/pandas/default.nix
@@ -21,6 +21,7 @@
 , tables
 , xlwt
 , runtimeShell
+, isPy38
 , libcxx ? null
 }:
 
@@ -67,7 +68,9 @@ in buildPythonPackage rec {
                 "['pandas/src/klib', 'pandas/src', '$cpp_sdk']"
   '';
 
-  setupPyBuildFlags = [
+  # Parallel Cythonization is broken in Python 3.8 on Darwin. Fixed in the next
+  # release. https://github.com/pandas-dev/pandas/pull/30862
+  setupPyBuildFlags = optionals (!(isPy38 && isDarwin)) [
     # As suggested by
     # https://pandas.pydata.org/pandas-docs/stable/development/contributing.html#creating-a-python-environment
     "--parallel=$NIX_BUILD_CORES"