diff --git a/pkgs/applications/emulators/resim/default.nix b/pkgs/applications/emulators/resim/default.nix
index 49d7721174f5..d69aafcec2bd 100644
--- a/pkgs/applications/emulators/resim/default.nix
+++ b/pkgs/applications/emulators/resim/default.nix
@@ -17,5 +17,10 @@ stdenv.mkDerivation {
     cp -v vc4emul/vc4emul $out/bin/vc4emul
   '';
 
+  cmakeFlags = [
+    # RPATH of binary /nix/store/.../bin/... contains a forbidden reference to /build/
+    "-DCMAKE_SKIP_BUILD_RPATH=ON"
+  ];
+
   meta.license = lib.licenses.mit;
 }
diff --git a/pkgs/applications/misc/edgetx/default.nix b/pkgs/applications/misc/edgetx/default.nix
index 4dfb5b6422fe..d71c01d4ace9 100644
--- a/pkgs/applications/misc/edgetx/default.nix
+++ b/pkgs/applications/misc/edgetx/default.nix
@@ -29,6 +29,8 @@ mkDerivation rec {
     "-DGTEST_ROOT=${gtest.src}/googletest"
     "-DQT_TRANSLATIONS_DIR=${qttranslations}/translations"
     "-DDFU_UTIL_PATH=${dfu-util}/bin/dfu-util"
+    # file RPATH_CHANGE could not write new RPATH
+    "-DCMAKE_SKIP_BUILD_RPATH=ON"
   ];
 
   meta = with lib; {
diff --git a/pkgs/applications/misc/opentx/default.nix b/pkgs/applications/misc/opentx/default.nix
index e0a7b8942444..e9a526a1f65f 100644
--- a/pkgs/applications/misc/opentx/default.nix
+++ b/pkgs/applications/misc/opentx/default.nix
@@ -31,6 +31,9 @@ mkDerivation rec {
     # XXX I would prefer to include these here, though we will need to file a bug upstream to get that changed.
     #"-DDFU_UTIL_PATH=${dfu-util}/bin/dfu-util"
     #"-DAVRDUDE_PATH=${avrdude}/bin/avrdude"
+
+    # file RPATH_CHANGE could not write new RPATH
+    "-DCMAKE_SKIP_BUILD_RPATH=ON"
   ];
 
   meta = with lib; {
diff --git a/pkgs/applications/science/logic/monosat/default.nix b/pkgs/applications/science/logic/monosat/default.nix
index e49c80db9d6e..2709b16c5770 100644
--- a/pkgs/applications/science/logic/monosat/default.nix
+++ b/pkgs/applications/science/logic/monosat/default.nix
@@ -47,6 +47,9 @@ let
       "-DBUILD_STATIC=OFF"
       "-DJAVA=${boolToCmake includeJava}"
       "-DGPL=${boolToCmake includeGplCode}"
+
+      # file RPATH_CHANGE could not write new RPATH
+      "-DCMAKE_SKIP_BUILD_RPATH=ON"
     ];
 
     postInstall = optionalString includeJava ''
diff --git a/pkgs/applications/science/misc/simgrid/default.nix b/pkgs/applications/science/misc/simgrid/default.nix
index 3afd997f70ff..4aaf6665b00c 100644
--- a/pkgs/applications/science/misc/simgrid/default.nix
+++ b/pkgs/applications/science/misc/simgrid/default.nix
@@ -65,6 +65,9 @@ stdenv.mkDerivation rec {
     "-Denable_compile_warnings=off"
     "-Denable_compile_optimizations=${optionOnOff optimize}"
     "-Denable_lto=${optionOnOff optimize}"
+
+    # RPATH of binary /nix/store/.../bin/... contains a forbidden reference to /build/
+    "-DCMAKE_SKIP_BUILD_RPATH=ON"
   ];
   makeFlags = optional debug "VERBOSE=1";
 
diff --git a/pkgs/development/libraries/fltk/common.nix b/pkgs/development/libraries/fltk/common.nix
index 6d0f90956b25..426a85e6a220 100644
--- a/pkgs/development/libraries/fltk/common.nix
+++ b/pkgs/development/libraries/fltk/common.nix
@@ -147,6 +147,9 @@ stdenv.mkDerivation rec {
     "-DOPTION_INSTALL_HTML_DOCUMENTATION=${onOff withDocs}"
     "-DOPTION_INSTALL_PDF_DOCUMENTATION=OFF"
     "-DOPTION_INCLUDE_DRIVER_DOCUMENTATION=${onOff withDocs}"
+
+    # RPATH of binary /nix/store/.../bin/... contains a forbidden reference to /build/
+    "-DCMAKE_SKIP_BUILD_RPATH=ON"
   ];
 
   preBuild = lib.optionalString (withCairo && withShared && stdenv.hostPlatform.isDarwin) ''
diff --git a/pkgs/development/libraries/libvisio2svg/default.nix b/pkgs/development/libraries/libvisio2svg/default.nix
index 0525ba80b4f9..b2a68ed58680 100644
--- a/pkgs/development/libraries/libvisio2svg/default.nix
+++ b/pkgs/development/libraries/libvisio2svg/default.nix
@@ -24,6 +24,11 @@ stdenv.mkDerivation rec {
   nativeBuildInputs = [ cmake ];
   buildInputs = [ libxml2 freetype librevenge libvisio libwmf libemf2svg ];
 
+  cmakeFlags = [
+    # file RPATH_CHANGE could not write new RPATH
+    "-DCMAKE_SKIP_BUILD_RPATH=ON"
+  ];
+
   meta = with lib; {
     description = "Library and tools to convert Microsoft Visio documents (VSS and VSD) to SVG";
     homepage = "https://github.com/kakwa/libvisio2svg";
diff --git a/pkgs/development/libraries/openhmd/default.nix b/pkgs/development/libraries/openhmd/default.nix
index a692dcb5e4e3..ce0630bee62f 100644
--- a/pkgs/development/libraries/openhmd/default.nix
+++ b/pkgs/development/libraries/openhmd/default.nix
@@ -37,6 +37,9 @@ stdenv.mkDerivation rec {
     "-DOPENHMD_EXAMPLE_SIMPLE=${examplesOnOff}"
     "-DOPENHMD_EXAMPLE_SDL=${examplesOnOff}"
     "-DOpenGL_GL_PREFERENCE=GLVND"
+
+    # RPATH of binary /nix/store/.../bin/... contains a forbidden reference to /build/
+    "-DCMAKE_SKIP_BUILD_RPATH=ON"
   ];
 
   postInstall = lib.optionalString withExamples ''
diff --git a/pkgs/development/tools/misc/sipp/default.nix b/pkgs/development/tools/misc/sipp/default.nix
index 0d5ceba12530..297669733c0e 100644
--- a/pkgs/development/tools/misc/sipp/default.nix
+++ b/pkgs/development/tools/misc/sipp/default.nix
@@ -18,6 +18,9 @@ stdenv.mkDerivation rec {
     "-DUSE_PCAP=1"
     "-DUSE_SSL=1"
     "-DUSE_SCTP=${if stdenv.isLinux then "1" else "0"}"
+
+    # file RPATH_CHANGE could not write new RPATH
+    "-DCMAKE_SKIP_BUILD_RPATH=ON"
   ];
   enableParallelBuilding = true;
 
diff --git a/pkgs/servers/geospatial/mapserver/default.nix b/pkgs/servers/geospatial/mapserver/default.nix
index 9ec9ad01bc87..e643f790bb57 100644
--- a/pkgs/servers/geospatial/mapserver/default.nix
+++ b/pkgs/servers/geospatial/mapserver/default.nix
@@ -47,6 +47,9 @@ stdenv.mkDerivation rec {
     "-DWITH_CURL=ON"
     "-DWITH_CLIENT_WMS=ON"
     "-DWITH_CLIENT_WFS=ON"
+
+    # RPATH of binary /nix/store/.../bin/... contains a forbidden reference to /build/
+    "-DCMAKE_SKIP_BUILD_RPATH=ON"
   ] ++ lib.optional withPython "-DWITH_PYTHON=ON";
 
   meta = with lib; {
diff --git a/pkgs/tools/networking/shadowsocks-libev/default.nix b/pkgs/tools/networking/shadowsocks-libev/default.nix
index 0584184a675e..3ad9161c716b 100644
--- a/pkgs/tools/networking/shadowsocks-libev/default.nix
+++ b/pkgs/tools/networking/shadowsocks-libev/default.nix
@@ -20,7 +20,10 @@ stdenv.mkDerivation rec {
   nativeBuildInputs = [ cmake asciidoc xmlto docbook_xml_dtd_45
                         docbook_xsl libxslt ];
 
-  cmakeFlags = [ "-DWITH_STATIC=OFF"  "-DCMAKE_BUILD_WITH_INSTALL_NAME_DIR=ON" ];
+  cmakeFlags = [ "-DWITH_STATIC=OFF"  "-DCMAKE_BUILD_WITH_INSTALL_NAME_DIR=ON"
+    # RPATH of binary /nix/store/.../bin/... contains a forbidden reference to /build/
+    "-DCMAKE_SKIP_BUILD_RPATH=ON"
+  ];
 
   postInstall = ''
     cp lib/* $out/lib