diff --git a/pkgs/development/libraries/itk/default.nix b/pkgs/development/libraries/itk/default.nix
index 08971c4c81c1..6816c37b9be6 100644
--- a/pkgs/development/libraries/itk/default.nix
+++ b/pkgs/development/libraries/itk/default.nix
@@ -5,6 +5,20 @@ stdenv.mkDerivation rec {
   pname = "itk";
   version = "5.2.1";
 
+  itkGenericLabelInterpolatorSrc = fetchFromGitHub {
+    owner = "InsightSoftwareConsortium";
+    repo = "ITKGenericLabelInterpolator";
+    rev = "2f3768110ffe160c00c533a1450a49a16f4452d9";
+    hash = "sha256-Cm3jg14MMnbr/sP+gqR2Rh25xJjoRvpmY/jP/DKH978=";
+  };
+
+  itkAdaptiveDenoisingSrc = fetchFromGitHub {
+    owner = "ntustison";
+    repo = "ITKAdaptiveDenoising";
+    rev = "24825c8d246e941334f47968553f0ae388851f0c";
+    hash = "sha256-deJbza36c0Ohf9oKpO2T4po37pkyI+2wCSeGL4r17Go=";
+  };
+
   src = fetchFromGitHub {
     owner = "InsightSoftwareConsortium";
     repo = "ITK";
@@ -16,16 +30,22 @@ stdenv.mkDerivation rec {
     substituteInPlace CMake/ITKSetStandardCompilerFlags.cmake  \
       --replace "-march=corei7" ""  \
       --replace "-mtune=native" ""
+    ln -sr ${itkGenericLabelInterpolatorSrc} Modules/External/ITKGenericLabelInterpolator
+    ln -sr ${itkAdaptiveDenoisingSrc} Modules/External/ITKAdaptiveDenoising
   '';
 
   cmakeFlags = [
     "-DBUILD_EXAMPLES=OFF"
     "-DBUILD_SHARED_LIBS=ON"
+    "-DITK_FORBID_DOWNLOADS=ON"
     "-DModule_ITKMINC=ON"
     "-DModule_ITKIOMINC=ON"
     "-DModule_ITKIOTransformMINC=ON"
     "-DModule_ITKVtkGlue=ON"
     "-DModule_ITKReview=ON"
+    "-DModule_MGHIO=ON"
+    "-DModule_AdaptiveDenoising=ON"
+    "-DModule_GenericLabelInterpolator=ON"
   ];
 
   nativeBuildInputs = [ cmake xz makeWrapper ];