diff --git a/pkgs/development/interpreters/python/sitecustomize.py b/pkgs/development/interpreters/python/sitecustomize.py
index e03b244dbc04..e59d6070cb6f 100644
--- a/pkgs/development/interpreters/python/sitecustomize.py
+++ b/pkgs/development/interpreters/python/sitecustomize.py
@@ -21,6 +21,10 @@ paths = os.environ.pop('NIX_PYTHONPATH', None)
 if paths:
     functools.reduce(lambda k, p: site.addsitedir(p, k), paths.split(':'), site._init_pathinfo())
 
+prefixes = os.environ.pop('NIX_PYTHONPREFIX', None)
+if prefixes:
+    site.PREFIXES.extend(prefixes.split(':'))
+
 executable = os.environ.pop('NIX_PYTHONEXECUTABLE', None)
 if 'PYTHONEXECUTABLE' not in os.environ and executable:
     sys.executable = executable
diff --git a/pkgs/development/interpreters/python/wrapper.nix b/pkgs/development/interpreters/python/wrapper.nix
index b437584024fe..dffad6b98f5e 100644
--- a/pkgs/development/interpreters/python/wrapper.nix
+++ b/pkgs/development/interpreters/python/wrapper.nix
@@ -37,7 +37,7 @@ let
             if [ -f "$prg" ]; then
               rm -f "$out/bin/$prg"
               if [ -x "$prg" ]; then
-                makeWrapper "$path/bin/$prg" "$out/bin/$prg" --set NIX_PYTHONEXECUTABLE ${pythonExecutable} --set NIX_PYTHONPATH ${pythonPath} ${if permitUserSite then "" else ''--set PYTHONNOUSERSITE "true"''} ${stdenv.lib.concatStringsSep " " makeWrapperArgs}
+                makeWrapper "$path/bin/$prg" "$out/bin/$prg" --set NIX_PYTHONPREFIX "$out" --set NIX_PYTHONEXECUTABLE ${pythonExecutable} --set NIX_PYTHONPATH ${pythonPath} ${if permitUserSite then "" else ''--set PYTHONNOUSERSITE "true"''} ${stdenv.lib.concatStringsSep " " makeWrapperArgs}
               fi
             fi
           done