diff --git a/pkgs/development/libraries/glibc/common.nix b/pkgs/development/libraries/glibc/common.nix
index 01563ffa656e..edf4d135aba7 100644
--- a/pkgs/development/libraries/glibc/common.nix
+++ b/pkgs/development/libraries/glibc/common.nix
@@ -103,7 +103,7 @@ stdenv.mkDerivation ({
     ++ lib.optional stdenv.buildPlatform.isDarwin ./darwin-cross-build.patch
 
     # Remove after upgrading to glibc 2.28+
-    ++ lib.optional (stdenv.hostPlatform != stdenv.buildPlatform) (fetchpatch {
+    ++ lib.optional (stdenv.hostPlatform != stdenv.buildPlatform || stdenv.hostPlatform.isMusl) (fetchpatch {
       url = "https://sourceware.org/git/?p=glibc.git;a=patch;h=780684eb04298977bc411ebca1eadeeba4877833";
       name = "correct-pwent-parsing-issue-and-resulting-build.patch";
       sha256 = "08fja894vzaj8phwfhsfik6jj2pbji7kypy3q8pgxvsd508zdv1q";
diff --git a/pkgs/development/libraries/glibc/default.nix b/pkgs/development/libraries/glibc/default.nix
index eda71af59783..50b359da96ce 100644
--- a/pkgs/development/libraries/glibc/default.nix
+++ b/pkgs/development/libraries/glibc/default.nix
@@ -40,7 +40,21 @@ callPackage ./common.nix { inherit stdenv; } {
     #      limit rebuilds by only disabling pie w/musl
       ++ stdenv.lib.optional stdenv.hostPlatform.isMusl "pie";
 
-    NIX_CFLAGS_COMPILE = if withGd then "-Wno-error=stringop-truncation" else null;
+    NIX_CFLAGS_COMPILE =
+      if !stdenv.hostPlatform.isMusl
+        # TODO: This (returning a string or `null`, instead of a list) is to
+        #       not trigger a mass rebuild due to the introduction of the
+        #       musl-specific flags below.
+        #       At next change to non-musl glibc builds, remove this `then`
+        #       and the above condition, instead keeping only the `else` below.
+        then (if withGd then "-Wno-error=stringop-truncation" else null)
+        else
+          builtins.concatLists [
+            (stdenv.lib.optional withGd "-Wno-error=stringop-truncation")
+            # Fix -Werror build failure when building glibc with musl with GCC >= 8, see:
+            # https://github.com/NixOS/nixpkgs/pull/68244#issuecomment-544307798
+            (stdenv.lib.optional stdenv.hostPlatform.isMusl "-Wno-error=attribute-alias")
+          ];
 
     # When building glibc from bootstrap-tools, we need libgcc_s at RPATH for
     # any program we run, because the gcc will have been placed at a new