diff --git a/pkgs/development/python-modules/pytest/default.nix b/pkgs/development/python-modules/pytest/default.nix
index 9412a750a9ab..45572938496c 100644
--- a/pkgs/development/python-modules/pytest/default.nix
+++ b/pkgs/development/python-modules/pytest/default.nix
@@ -3,7 +3,7 @@
 , atomicwrites, mock, writeText, pathlib2
 }:
 buildPythonPackage rec {
-  version = "3.9.3";
+  version = "4.2.1";
   pname = "pytest";
 
   preCheck = ''
@@ -13,7 +13,7 @@ buildPythonPackage rec {
 
   src = fetchPypi {
     inherit pname version;
-    sha256 = "a9e5e8d7ab9d5b0747f37740276eb362e6a76275d76cebbb52c6049d93b475db";
+    sha256 = "c2396a15726218a2dfef480861c4ba37bd3952ebaaa5b0fede3fc23fddcd7f8c";
   };
 
   checkInputs = [ hypothesis mock ];
@@ -24,7 +24,7 @@ buildPythonPackage rec {
 
   checkPhase = ''
     runHook preCheck
-    $out/bin/py.test -x testing/
+    $out/bin/py.test -x testing/ -k "not test_collect_pyargs_with_testpaths"
     runHook postCheck
   '';
 
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 93355ba46e49..e00567e8020f 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -299,7 +299,7 @@ in {
   cdecimal = callPackage ../development/python-modules/cdecimal { };
 
   cfn-flip = callPackage ../development/python-modules/cfn-flip { };
- 
+
   chalice = callPackage ../development/python-modules/chalice { };
 
   cleo = callPackage ../development/python-modules/cleo { };
@@ -1493,9 +1493,9 @@ in {
 
   pyhepmc = callPackage ../development/python-modules/pyhepmc { };
 
-  pytest = self.pytest_39;
+  pytest = self.pytest_42;
 
-  pytest_39 = callPackage ../development/python-modules/pytest {
+  pytest_42 = callPackage ../development/python-modules/pytest {
     # hypothesis tests require pytest that causes dependency cycle
     hypothesis = self.hypothesis.override { doCheck = false; };
   };