diff --git a/packages/pyright-internal/src/analyzer/typeEvaluator.ts b/packages/pyright-internal/src/analyzer/typeEvaluator.ts
index cafa4ad35..40528de0d 100644
--- a/packages/pyright-internal/src/analyzer/typeEvaluator.ts
+++ b/packages/pyright-internal/src/analyzer/typeEvaluator.ts
@@ -396,6 +396,7 @@ interface AliasMapEntry {
     alias: string;
     module: 'builtins' | 'collections' | 'self';
     isSpecialForm?: boolean;
+    typeParamVariance?: Variance;
 }
 
 interface AssignClassToSelfInfo {
@@ -15547,6 +15548,20 @@ export function createTypeEvaluator(importLookup: ImportLookup, evaluatorOptions
             specialClassType.details.flags |= ClassTypeFlags.SpecialFormClass;
         }
 
+        // Synthesize a single type parameter with the specified variance if
+        // specified in the alias map entry.
+        if (aliasMapEntry.typeParamVariance !== undefined) {
+            let typeParam = TypeVarType.createInstance('T');
+            typeParam = TypeVarType.cloneForScopeId(
+                typeParam,
+                ParseTreeUtils.getScopeIdForNode(node),
+                assignedName,
+                TypeVarScopeType.Class
+            );
+            typeParam.details.declaredVariance = aliasMapEntry.typeParamVariance;
+            specialClassType.details.typeParameters.push(typeParam);
+        }
+
         const specialBuiltInClassDeclaration = (AnalyzerNodeInfo.getDeclaration(node) ??
             (node.parent ? AnalyzerNodeInfo.getDeclaration(node.parent) : undefined)) as
             | SpecialBuiltInClassDeclaration
@@ -15629,7 +15644,10 @@ export function createTypeEvaluator(importLookup: ImportLookup, evaluatorOptions
             ['Annotated', { alias: '', module: 'builtins', isSpecialForm: true }],
             ['TypeAlias', { alias: '', module: 'builtins', isSpecialForm: true }],
             ['Concatenate', { alias: '', module: 'builtins', isSpecialForm: true }],
-            ['TypeGuard', { alias: '', module: 'builtins', isSpecialForm: true }],
+            [
+                'TypeGuard',
+                { alias: '', module: 'builtins', isSpecialForm: true, typeParamVariance: Variance.Covariant },
+            ],
             ['Unpack', { alias: '', module: 'builtins', isSpecialForm: true }],
             ['Required', { alias: '', module: 'builtins', isSpecialForm: true }],
             ['NotRequired', { alias: '', module: 'builtins', isSpecialForm: true }],
@@ -15638,7 +15656,7 @@ export function createTypeEvaluator(importLookup: ImportLookup, evaluatorOptions
             ['Never', { alias: '', module: 'builtins', isSpecialForm: true }],
             ['LiteralString', { alias: '', module: 'builtins', isSpecialForm: true }],
             ['ReadOnly', { alias: '', module: 'builtins', isSpecialForm: true }],
-            ['TypeIs', { alias: '', module: 'builtins', isSpecialForm: true }],
+            ['TypeIs', { alias: '', module: 'builtins', isSpecialForm: true, typeParamVariance: Variance.Invariant }],
         ]);
 
         const aliasMapEntry = specialTypes.get(assignedName);
@@ -23522,7 +23540,7 @@ export function createTypeEvaluator(importLookup: ImportLookup, evaluatorOptions
                     return !isLiteral;
                 }
             } else if (ClassType.isBuiltIn(destType, ['TypeGuard', 'TypeIs'])) {
-                // All the source to be a "bool".
+                // Allow the source to be a "bool".
                 if ((originalFlags & AssignTypeFlags.AllowBoolTypeGuard) !== 0) {
                     if (isClassInstance(srcType) && ClassType.isBuiltIn(srcType, 'bool')) {
                         return true;
diff --git a/packages/pyright-internal/src/tests/samples/typeGuard1.py b/packages/pyright-internal/src/tests/samples/typeGuard1.py
index 0525f5fac..41e9160ad 100644
--- a/packages/pyright-internal/src/tests/samples/typeGuard1.py
+++ b/packages/pyright-internal/src/tests/samples/typeGuard1.py
@@ -5,7 +5,7 @@
 # pyright: reportMissingModuleSource=false
 
 import os
-from typing import Any, TypeVar
+from typing import Any, Callable, TypeVar
 from typing_extensions import TypeGuard  # pyright: ignore[reportMissingModuleSource]
 
 _T = TypeVar("_T")
@@ -100,3 +100,26 @@ def func4(typ: type[_T]) -> _T:
         raise Exception("Unsupported type")
 
     return typ()
+
+
+def takes_int_typeguard(f: Callable[[object], TypeGuard[int]]) -> None:
+    pass
+
+
+def int_typeguard(val: object) -> TypeGuard[int]:
+    return isinstance(val, int)
+
+
+def bool_typeguard(val: object) -> TypeGuard[bool]:
+    return isinstance(val, bool)
+
+
+def str_typeguard(val: object) -> TypeGuard[str]:
+    return isinstance(val, str)
+
+
+takes_int_typeguard(int_typeguard)
+takes_int_typeguard(bool_typeguard)
+
+# This should generate an error because TypeGuard is covariant.
+takes_int_typeguard(str_typeguard)
diff --git a/packages/pyright-internal/src/tests/samples/typeIs1.py b/packages/pyright-internal/src/tests/samples/typeIs1.py
index 3a8bc7805..4d89afe40 100644
--- a/packages/pyright-internal/src/tests/samples/typeIs1.py
+++ b/packages/pyright-internal/src/tests/samples/typeIs1.py
@@ -1,6 +1,6 @@
 # This sample tests the TypeIs form.
 
-from typing import Any, Literal, Mapping, Sequence, TypeVar, Union
+from typing import Any, Callable, Literal, Mapping, Sequence, TypeVar, Union
 from typing_extensions import TypeIs  # pyright: ignore[reportMissingModuleSource]
 
 
@@ -88,7 +88,23 @@ def is_marsupial(val: Animal) -> TypeIs[Kangaroo | Koala]:
 
 
 # This should generate an error because list[T] isn't consistent with list[T | None].
-def has_no_nones(
-    val: list[T | None],
-) -> TypeIs[list[T]]:
+def has_no_nones(val: list[T | None]) -> TypeIs[list[T]]:
     return None not in val
+
+
+def takes_int_typeis(f: Callable[[object], TypeIs[int]]) -> None:
+    pass
+
+
+def int_typeis(val: object) -> TypeIs[int]:
+    return isinstance(val, int)
+
+
+def bool_typeis(val: object) -> TypeIs[bool]:
+    return isinstance(val, bool)
+
+
+takes_int_typeis(int_typeis)
+
+# This should generate an error because TypeIs is invariant.
+takes_int_typeis(bool_typeis)
diff --git a/packages/pyright-internal/src/tests/typeEvaluator3.test.ts b/packages/pyright-internal/src/tests/typeEvaluator3.test.ts
index 3d67d43ad..cc3da5afd 100644
--- a/packages/pyright-internal/src/tests/typeEvaluator3.test.ts
+++ b/packages/pyright-internal/src/tests/typeEvaluator3.test.ts
@@ -1013,7 +1013,7 @@ test('EnumGenNextValue1', () => {
 test('TypeGuard1', () => {
     const analysisResults = TestUtils.typeAnalyzeSampleFiles(['typeGuard1.py']);
 
-    TestUtils.validateResults(analysisResults, 7);
+    TestUtils.validateResults(analysisResults, 8);
 });
 
 test('TypeGuard2', () => {
@@ -1029,7 +1029,7 @@ test('TypeGuard3', () => {
 
 test('TypeIs1', () => {
     const analysisResults = TestUtils.typeAnalyzeSampleFiles(['typeIs1.py']);
-    TestUtils.validateResults(analysisResults, 1);
+    TestUtils.validateResults(analysisResults, 2);
 });
 
 test('Never1', () => {