diff --git a/src/js.rs b/src/js.rs
index 8c9e9deb4..6aac7093e 100644
--- a/src/js.rs
+++ b/src/js.rs
@@ -92,7 +92,12 @@ extern {
     #[wasm_bindgen(method, js_name = toString)]
     pub fn to_string(this: &Object) -> String;
 
-
+    /// The isPrototypeOf() method checks if an object exists in another
+    /// object's prototype chain.
+    /// 
+    /// https://developer.mozilla.org/en-US/docs/Web/JavaScript/Reference/Global_Objects/Object/isPrototypeOf
+    #[wasm_bindgen(method, js_name = isPrototypeOf)]
+    pub fn is_prototype_of(this: &Object, value: &JsValue) -> bool;
 }
 
 // Array
diff --git a/tests/all/js_globals/Object.rs b/tests/all/js_globals/Object.rs
index 487f57441..80ac388d1 100755
--- a/tests/all/js_globals/Object.rs
+++ b/tests/all/js_globals/Object.rs
@@ -87,3 +87,34 @@ fn to_string() {
         "#)
         .test()
 }
+
+#[test]
+fn is_prototype_of() {
+    project()
+        .file("src/lib.rs", r#"
+            #![feature(proc_macro, wasm_custom_section)]
+
+            extern crate wasm_bindgen;
+            use wasm_bindgen::prelude::*;
+            use wasm_bindgen::js;
+
+            #[wasm_bindgen]
+            pub fn obj_is_prototype_of_value(obj: &js::Object, value: &JsValue) -> bool {
+                obj.is_prototype_of(&value)
+            }
+        "#)
+        .file("test.ts", r#"
+            import * as assert from "assert";
+            import * as wasm from "./out";
+
+            class Foo {}
+            class Bar {}
+
+            export function test() {
+                const foo = new Foo();
+                assert(wasm.obj_is_prototype_of_value(Foo.prototype, foo));
+                assert(!wasm.obj_is_prototype_of_value(Bar.prototype, foo));
+            }
+        "#)
+        .test()
+}