diff --git a/.changes/isolation-script-remove-itself.md b/.changes/isolation-script-remove-itself.md
new file mode 100644
index 000000000..f7b0888df
--- /dev/null
+++ b/.changes/isolation-script-remove-itself.md
@@ -0,0 +1,5 @@
+---
+"tauri-utils": patch:enhance
+---
+
+The isolation iframe script now removes itself after execution.
diff --git a/core/tauri-utils/src/pattern/isolation.js b/core/tauri-utils/src/pattern/isolation.js
index b87f479fb..f1908bffc 100644
--- a/core/tauri-utils/src/pattern/isolation.js
+++ b/core/tauri-utils/src/pattern/isolation.js
@@ -135,4 +135,6 @@
   }
 
   setTimeout(waitUntilReady, readyIntervalMs)
+
+  document.currentScript.remove()
 })()