wezterm/docs/serial.md

wezterm can also connect to serial ports as a client. This is useful for example when working with embedded devices such as Arduino, or when connecting to a serial console on a headless server.

For example, on Linux:

$ wezterm serial /dev/ttyUSB0

or on Windows:

$ wezterm serial COM0

You can also specify the baud rate:

$ wezterm serial --baud 38400 /dev/ttyUSB0

When a wezterm window is operating in serial mode it is not possible to create new tabs.